Planning a large river monitoring campaign is not an easy task. One may expect that upon the field many things turn wrong. To prevent experimental failures and to plan ahead the field work, in July 2019, Andreu Rico visited Andrea Waichman in Manaus (Brazil). During that visit some preliminary water, plant and fish samples were taken, mainly to test sampling procedures and analytical methods. The results of this trial show that wastewaters dumped into the Amazon River contain a wide range of pharmaceuticals and life style compounds, and fish and plant samples accumulate several persistent organic pollutants and fragrances. These primary findings suggest that synthetic chemicals have reached the highly biodiverse Amazonian ecosystems, and therefore have raised high expectations for the upcoming SILENT AMAZON Expedition!